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The ABO Blood Group System

The ABO Blood Group System - раздел Образование, E 2.5: Hypersensitivity Allergy ...

A person's ABO blood type depends on the presence or absence of carbohydrate antigens located on the cell membranes of red blood cells (RBCs). Cells of blood type 0 lack both A and B antigens. The plasma of individuals with a given blood type, such as A, have antibodies against the alternative blood type, anti-B antibody. These antibodies are presumed to arise in response to microorganisms and ingested foodstuffs that have antigenic determinants very similar to blood group antigens. Individuals with type AB cells have plasma with no antibodies to either A or B antigens. Type 0 individuals have antibodies against both A and B antigens.

When a transfusion is incompatible, as when type B blood is transfused into a person with type A blood, the antigens on the type B blood cells will react with anti-B antibodies in the recipient's serum. This antigen- antibody reaction activates complement, which in turn causes lysis of the donor's RBCs as they enter the recipient’s system.

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E 2.5: Hypersensitivity Allergy

Plan... Type I Anaphylactic... Type II Cytotoxic Reactions...

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Type I (Anaphylactic) Reactions
Type I, or anaphylactic, react ions often occur within 2 to 30 minutes after a person sensitized to an antigen is reexposed to that antigen. Anaphylaxis means opposite of protected," fr

Systemic Anaphylaxis
At the turn of the twentieth century, two French biologists studied the responses of dogs to the venom of stinging jellyfish. Large doses of venom usually killed the dogs, but sometimes a few survi

Localized Anaphylaxis
Whereas sensitization to injected antigens is a common cause of systemic anaphylaxis, localized anaphylaxis is usually associated with antigens that are ingested (foods) or inhaled (pollen). The sy

The Rh Blood Group System
In the 1930s, researchers discovered the presence of a different surface antigen on human red blood cells. Soon after they injected rabbits with RBCs from rhesus monkeys, the rabbit serum contained

Type III (Immune Complex) Reactions
Type III reactions involve antibodies against soluble antigens circulating in the serum. (In contrast, type II immune reactions are directed against antigens located on cell or tissue surfaces.) Im

Figure 4 Immune complex-mediated hypersensitivity.
Figure 5 The development of an allergy (allergic contact dennatitis) to catechols from the poison ivy plant. Pent

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